HPTU B.Pharmacy 6th Sem Theory Syllabus

12 August, 2022
Conducted by : HPTU Hamirpur

HPTU Hamirpur B.Pharmacy 6th Semester Theory Syllabus:

MEDICINAL CHEMISTRY – II (BP-361)
INSTRUCTIONS

1. For Paper Setters: The question paper will consist of THREE sections A, B and C. Section A will
contain THREE Essay Type Questions of 10 marks each. Section B will contain TEN Short Answer
Type Questions carrying 5 marks each. Section C will contain FIVE Short Note Type Questions
carrying 2 marks each. In this section, all the questions are COMPULSORY. The questions should
be normally selected from all the chapters of the subject. The weightage is based on the teaching
hours specified against each chapter.

2. For Candidates: The candidates are required to attempt ANY TWO questions from Section A,
ANY EIGHT questions from Section B. Section C will be compulsory and students have to answer
ALL questions from Section C.

Theory (40 Hrs: 3 Hrs / Week)

1. Cardiovascular Agents: Nomenclature, stereochemistry, Synthesis, mode of action, uses,
structure activity relationship, physicochemical properties of cardiovascular drugs like cardiac
glycosides, antihypertensives, antianginal drugs, antiarrhythmics and vasodilators. (5 Hrs)

2. Drugs acting on Hemopoietic System: Nomenclature, stereochemistry, Synthesis, mode of
action, uses, structure activity relationship, physicochemical properties of anticoagulants and anti-
platelet drugs. (3 Hrs)

3. Drugs Acting on Urinary System: Nomenclature, stereochemistry, Synthesis, mode of action,
uses, structure activity relationship, physico-chemical properties of Diuretics. (2 Hrs)

4. Autocoids: Nomenclature, stereochemistry, Synthesis, mode of action, uses, structure activity
relationship, physico-chemical properties of antihistaminic drugs, eicosanoids. (5 Hrs)

5. Anti-inflammatory Drugs: Nomenclature, stereochemistry, Synthesis, mode of action, uses,
structure activity relationship, physico-chemical properties of opoid analgesics and non-steroidal
anti-inflammatory agents. (7 Hrs)

6. Steroids and Related Drugs: Nomenclature of steroids, stereochemistry, synthesis, mode of
action, uses, structure activity relationship, physico-chemical properties of androgens, anabolic
steroids, estrogens, progestational agents, adrenocorticoids. (8 Hrs)

7. Drugs Affecting Uterine Motility: Oxytocics (including oxytocin, ergot alkaloids and
prostaglandins). (7 Hrs)

8. Antidiabetic Drugs: Insulin and oral hypoglycaemic agents. (3 Hrs)

Books Recommended
Note: Recent editions of the following books to be referred
1. Foye WC. Principles of Medicinal Chemistry. Philadelphia: Lea & Febiger.
2. Beale JM, Block JH. Wilson and Gisvold’s Text book of Organic Medicinal and Pharmaceutical
Chemistry. Philadelphia: Lippincott Williams and Wilkins.
3. Hansh C. Comprehensive Medicinal Chemistry - Quantitative Drug Design. Vol. IV. Oxford:
Pergamon Press.
4. Wolff ME. Burger’s Medicinal Chemistry. New York: John Wiley & Sons.
5. Nogrady T. Medicinal Chemistry – A Biochemical Approach. Oxford: Oxford University Press.
6. Lednicer D, Mitscher LA. The Organic Chemistry of Drug Synthesis. Vol. 1. New York: John Wiley
& Sons.

CHEMISTRY OF NATURAL PRODUCTS (BP-362)
Theory (40 Hrs: 3 Hrs / Week)

1. Terpenoids: Chemistry, and pharmacological activity of medicinally important monoterpenes
(Citral, Camphor, Menthol), sesquiterpenes (Faniol), diterpenes (Abietic Acid), and triterpenoids
(Amyrins). (8 Hrs)

2. Carotenoids: α-carotenoids, β-carotenes, vitamin A, and xanthophylls of medicinal importance.
(6 Hrs)

3. Glycosides: Chemistry, pharmacological activity of digitoxin, digoxin, sennosides and diosgenin.
(6 Hrs)

4. Alkaloids: Chemistry, and pharmacological activity of atropine and related compounds, quinine,
reserpine, morphine, papaverine, ephedrine, ergot and vinca alkaloids. (10 Hrs)

5. Antibiotics: Chemistry and therapeutic activity of penicillin, streptomycin and tetracycline. (5 Hrs)

6. Flavonoids: Chemistry and pharmacological activity of medicinally important flavonoids such as
flavones, flavonols, quercetin, isoflavones. (5 Hrs)

Books Recommended
Note: Recent editions of the following books to be referred
1. Finar IL. Organic Chemistry. Vol.II. London: ELBS/Longman.
2. Harborne JB. Phytochemical Methods. London: Chapman & Hall.
3. Manitto P. The Biosynthesis of Natural Products. Chichester: Ellis Horwood.
4. De Mayo P. The Chemistry of Natural Products. New York: Wiley Interscience.
5. Pridham JB. Terpenoids in Plants. New York: Academic Press.
6. Pridham JB, Swain T. Biosynthetic Pathways in Higher Plants. New York: Academic Press.
7. Rabinson T. The Biochemistry of Alkaloids, Springer Verlag, New York.

PHARMACOLOGY – II (BP-363)
Theory (40 Hrs: 3 Hrs / Week)

1. Pharmacology of Cardiovascular System: Digitalis and cardiac glycosides, Antihypertensive
drugs, Antianginal and Vasodilator drugs including calcium channel blockers and beta adrenergic
antagonists, Antiarrhythmic drugs, Antihyperlipedemic drugs, Drugs used in the therapy of shock.
(12 Hrs)

2. Drugs Acting on Hemopoietic System: Hematinics, Anticoagulants, Vitamin K and hemostatic
agents, Fibrinolytic and anti-platelet drugs, Blood and plasma volume expanders. (6 Hrs)

3. Drugs Acting on Urinary System: Fluid and electrolyte balance, Diuretics. (5 Hrs)

4. Autocoids: Histamine, 5-HT and their antagonists, Prostaglandins, thromboxanes and
leukotrienes, Pentagastrin, Cholecystokinin, Angiotensin, Bradykinin. (5 Hrs)

5. Pharmacology of Endocrine System: Hypothalamic and pituitary hormones, Thyroid hormones
and anti-thyroid drugs, parathormone, calcitonin and Vitamin D. (5 Hrs)

6. Antidiabetic Agents: Insulin, oral hypoglycaemic agents and glucagon. (3 Hrs)

7. Steroids and Related Drugs: ACTH, corticosteroids, Androgens and anabolic steroids,
Estrogens, progesterone and oral contraceptives, Drugs acting on the uterus. (4 Hrs)

Books Recommended
Note: Recent editions of the following books to be referred
1. Rang MP, Dale MM, Riter JM. Pharmacology. New York: Churchill Livingstone.
2. Brunton LL, Lazo JS, Parker KL. Goodman and Gilman’s The Pharmacological Basis of
Therapeutics. New York: McGraw Hill.
3. Mycek MJ, Harvey RA, Champe PC. Lipponcott’s Illustrated Reviews - Pharmacology.
Philadelphia: Lippincott Williams & Wilkins.
4. Tripathi KD. Essential of medical Pharmacology, New Delhi: Jaypee Brothers Medical Publishers.
5. Ghosh MN. Fundamentals of Experimental Pharmacology. Scientific Book Agency, Kolkatta.
6. Kulkarni SK. Handbook of Experimental Pharmacology. Vallabh Prakashan, Delhi.

PHARMACEUTICAL TECHNOLOGY – I (BP-364)
Theory (40 Hrs: 3 Hrs / Week)

1. Preformulation: Introduction to preformulation, study of physical properties of drugs like
organoleptic properties, physical form, particle size, shape, density, wetting, dielectric constant,
solubility, dissolution and their effect on formulation, stability and bioavailability. (8 Hrs)

2. Stability: Stability testing of various pharmaceutical products as per international guidelines such
as ICH, WHO, CPMP and USFDA. Stabilization of pharmaceutical products. Pro-drug approachfor solving stability problems. (5 Hrs)

3. Liquid Dosage Forms: Introduction, Types of additives used in formulations -vehicles,
stabilizers, preservatives, suspending agents, emulsifying agents, solubilizer, colors, flavours
and others, manufacturing, packaging and evaluation of clear liquids, suspensions and emulsions
official in pharmacopoeia. (5 Hrs)

4. Semisolid Dosage Forms: Definition, types, mechanisms of drug penetration, factors
influencing penetration, semisolid bases and their selection. General formulation of semisolids,
clear gels manufacturing procedure, evaluation and packaging. (4 Hrs)

5. Suppositories: Ideal requirements, bases, manufacturing procedure, packaging and evaluation.
(2 Hrs)

6. Extraction and Galenical Products: Principle and method of extraction, preparation of infusion,
tinctures, dry and soft liquid extracts. (3 Hrs)

7. Blood Products and Plasma Substitutes: Collection, processing and storage of whole human
blood, concentrated human RBCs, dried human plasma, human fibrinogen, human thrombin,
human normal immunoglobulin, human fibrin, foam plasma substitutes -ideal requirements,
properties of plasma substitutes like PVP, dextran, etc. (3 Hrs)

8. Cosmeticology and Cosmetic Preparations: Fundamentals of cosmetic science, structure and
functions of skin and hair. Formulation, preparation and packaging of cosmetics for skin, hair,
dentifrice and manicure preparations like nail polish, Lipsticks, eye lashes, baby care products.
(10 Hrs)

Books Recommended
Note: Recent editions of the following books to be referred
1. Aulton ME. Pharmaceutics-The Science of Dosage Form Design. London: ELBS/Churchill
Livingstone.
2. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy.
Philadelphia: Lea & Febiger.
3. Ansel HC. Introduction to Pharmaceutical Dosage Forms. Mumbai: Verghese & Co.
4. Banker GS, Rhodes CT. Modern Pharmaceutics. New York: Marcel Dekker.
5. Jellinek JS. Formulation and Function of Cosmetics. New York: John Wiley & Sons.
6. Rawlins EA. Bentley’s Textbook of Pharmaceutics. London: ELBS.
7. Thomssen SG. Modern Cosmetics, Mumbai: Universal Publishing.

CLINICAL PHARMACY (BP-365)
Theory (40 Hrs: 3 Hrs / Week)

1. Introduction: Introduction to Clinical Pharmacy, drug-drug and drug-food interactions. (2 Hrs)

2. Basic Concepts of Pharmacotherapy: Clinical Pharmacokinetics and individualization of Drug
Therapy; Drug Delivery Systems and their Biopharmaceutic & Therapeutic Considerations; Drug
Use During Infancy and in the Elderly (Pediatries & Geriatrics); Drug use during Pregnancy; Drug
induced Diseases; The Basics of Drug Interactions; General Principles of Clinical Toxicology;
Interpretation of Clinical Laboratory Tests. (10 Hrs)

3. Cardiovascular and Hematopoietic Disorders: Management of Hypertension, Congestive Heart
Failure, Angina, Acute Myocardial Infarction, Cardiac arrhythmias, different types of anemias. (4
Hrs)

4. Management of CNS Disorders: Epilepsy, Parkinsonism, Schizophrenia, Depression. (2 Hrs)

5. Management of Respiratory Diseases: Asthma, tuberculosis and other Upper Respiratory
Infections. (3 Hrs)

6. Management of Gastrointestinal Disorders: Pepticulcer, Ulcerative colitis, Hepatitis, Cirrhosis,
Enteric Infections. (3 Hrs)

7. Endocrine Disorders: Diabetesmellitus, Thyroid Disorders. (2 Hrs)

8. Urinogenital Infections: Management of Urinary Tract Infections.(2 Hrs)

9. Joint and Connective Tissue Disorders: Rheumatic Diseases, Gout and Hyper-uricemia. (2
Hrs)

10. Neoplastic Diseases: AcuteLeukaemias, Hodgkin's disease.(2 Hrs)

11. Therapeutic Drug Monitoring: Introduction to therapeutic drug monitoring, its significance and
methods of monitoring. (5Hrs)

12. Essential Drugs and Rational Drug Use: Definitions, Concept of essential drugs and rational
use of drugs, List of essential drugs by WHO, WHO guidelines on rational use of drugs and their
combinations. (3 Hrs)

Books Recommended

Note: Recent editions of the following books to be referred
1. Herfindel ET, Hirshman JL. Clinical Pharmacy and Therapeutics.New York: Lippincott Williams &
Wilkins.
2. Gennaro AD. Remington’s: The Science and Practice of Pharmacy. Pennsylvania: Mack
Publishing Co.
3. Dipiro JL. Pharmacotherapy: A Pathophysiological Approach. Elsevier.
4. Katzung BG. Basic and Clinical Pharmacology.New York: Prentice Hall.
5. Laurence DR, Bennet PN. Clinical Pharmacology.London: Churchil Livingstone.
6. Rowland M, Tozer TN. Clinical Pharmacokinetics.New York: Lea and Febiger.
7. Winter M.E. Basic Clinical Pharmacokinetics.San Francisco: Applied Therapeutics Inc.

PHARMACEUTICAL JURISPRUDENCE AND INTELLECTUAL PROPERTY RIGHTS (BP-366)

Theory (40 Hrs: 3 Hrs / Week)

Note: The teaching of all the below acts should cover the latest amendments.

1. Introduction: Brief review of Pharmaceutical Legislations, Drugs & Pharmaceutical Industry, and
Pharmaceutical Education. (3 Hrs)

2. An elaborate study of thefollowing: (7 Hrs)
a. Pharmaceutical Ethics
b. Pharmacy Act 1948.
c. Drugs and Cosmetics Act 1940 and Rules 1945.
d. Medicinal & Toilet Preparations (Excise Duties) Act 1955.
e. Narcotic Drugs & Psychotropic Substances Act 1985 & Rules.
f. Drugs Price Control Order.

3. A brief study of the following with special reference to the main provisions: (10 Hrs)
a. Poisons Act 1919
b. Drugs and Magic Remedies (Objectionable Advertisements) Act 1954
c. Medical Termination of Pregnancy Act 1970 & Rules 1975.
d. Prevention of Cruelty to Animals Act 1960.
e. States Shops & Establishments Act & Rules.
f. Insecticides Act 1968.
g. AICTE Act 1987.
h. Factories Act 1948.
i. Minimum Wages Act 1948.

4. Intellectual Property-Concepts and Fundamentals: The emergence and growth of the concepts
regarding intellectual property (IP), intellectual property protection (IPP) and intellectual property
rights (IPR); economic importance, mechanism for protection of intellectual property-patents. (5 Hrs)

5. Patenting: Copyright and trade mark protection, criteria for patentability, Indian Patent Act 1970 and amendments to Indian Patent Act 1970, basic considerations, filing of a patent application, grant of patent. (5 Hrs)

6. Trade Related Aspects of Intellectual Property Rights: Intellectual property and international
trade, concept behind WTO (World Trade Organization), WIPO (World Intellectual Property
Organization), GATT (General Agreement on Tariff and Trade), TRIPs (Trade Related Intellectual
Property Rights), TRIMS (Trade Related Investment Measures) and GATS (General Agreement on
Trades in Services), status in India and other developing countries. (10 Hrs)

Books Recommended
Note: Recent editions of the following books to be referred
1. Jain, NK. Textbook of Forensic Pharmacy. New Delhi: Vallabh Prakashan.
2. Mithal BM. Textbook of Forensic Pharmacy. Kolkatta: National Book Depot.
3. Bharti HK. Drugs & Pharmacy Laws in India. Indore: Sadhna Mandir.
4. Wadedhra BL. Law Relating to Patents, Trademarks, Copyright Design and Geographical
Indications. New Delhi: Universal Law Publishing.
5. Bansal P. IPR Handbook for Pharma Students and Researchers. Hyderabad: Pharma Book
Syndicate.
6. Trivedi PR. Encylcopedia of Intellectual Property Rights. New Delhi: Jnanada Prakashan.
7. Acts related to Pharmacy Education and Practice: AICTE Act 1987, Drug and Cosmetics Act,
1940 and Rules 1945, Drugs and Magic Remedies (Objectionable Advertisements) Act 1954,
Drugs Price Control Order (DPCO), Factories Act 1948, Insecticides Act 1968, Medicinal & Toilet
Preparations (Excise Duties) Act 1955, Medical Termination of Pregnancy Act (MTPA) 1970 &
Rules 1975, Minimum Wages Act 1948, Narcotic Drugs & Psychotropic Substances Act 1985 &
Rules, Pharmacy Act 1948, Poisons Act 1919.



Exams Conducted by : HPTU Hamirpur (Himachal Pradesh)
Syllabus for Exam : B.Pharmacy
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